South Main Building | New Luxury Apartments in Houston, TX | Now Leasing

Contact us today for current specials!

Contact Us

Modern Tradition

Featuring the best of contemporary comforts, while paying homage to the area’s history and sense of values, South Main Building establishes a Modern Tradition in the heart of Houston. Located in the Texas Medical Center, South Main residents enjoy walkability to some of the city’s premier destinations.


Situated in the cultural heart of Houston and surrounded by the Houston Museum District, an urban park, a private university and one of Houston’s most prestigious historic neighborhoods, South Main provides cosmopolitan living to the modern TMC urbanite.

Exceptional Service

An onsite concierge acts as your personal “lifestyle manager” – available to make life less hectic, so you can focus on what matters most.

Urban Accessibility

With short car or bike commutes and access to world-class museums and historic parks, South Main Building offers rare proximity to Houston’s best.

Chic Surroundings

Offering urban convenience with a timeless touch, South Main Building is classically designed to contribute to the community’s architectural landscape and cultural aesthetic.

Cosmopolitan Living

Featuring the latest amenities and comforts, South Main Building was constructed with respect for the area’s history and sense of values.

30-Day Satisfaction Guarantee

We’re committed to providing the best in apartment living. Ask our onsite team about our 30-Day Satisfaction Guarantee.

Contemporary Classic

Each residence at South Main offers a fresh approach to modernist design – equal parts classic and contemporary. All finish schemes feature inviting open floor plans and large, expansive windows with abundant natural light and sweeping views of Houston beyond.

Find Your Perfect Space »


Offering every convenience of modern urban living with a classic cultural aesthetic, the amenities at South Main allow you to stay connected to your professional life or provide an escape from it.

Find Your Escape »


Centered within the Texas Medical Center – a city within the city containing the world’s largest medical complex – South Main offers a rare proximity to Houston’s cultural heart. Residents are within a walkable radius of world-renowned museums, a historic urban park, and an elegant architectural and natural landscape.

Explore Your City »


Take a photo tour and experience the elegant surroundings of your new home and the highlights of the surrounding neighborhood.

See For Yourself »

Classic Taste, Your Priorities

With one- and two-bedroom apartment homes designed for the professional lifestyle, South Main is the definitive example of Modern Tradition. Contact us today to take the next step in making our community your new home.

Connect With Us »


At South Main Building, you will find an exceptional apartment living experience in one of the most desirable neighborhoods in Houston. Your new Texas Medical Center apartment embodies the timeless aesthetic of the surrounding architecture and delivers every urban convenience with access to employment, restaurants, shopping, and unmatched cultural destinations.